Arthritis and autoimmune diseases physician resources

Our resource center includes a host of Quest Diagnostics educational and clinical laboratory resources for clinicians who treat patients with arthritis and autoimmune diseases. From webinars and CME programs to expert insights and publications, it’s all valuable information to help support you in making better clinical decisions regarding diagnosis, treatment monitoring and prognosis.

The role of laboratory testing in the treatment of arthritis and autoimmune disease
2014 TR 2 Target (T2T) Guidelines
Biomarkers of early diagnosis
Spotlight on 14-3-3 eta
Irritable bowel disease (IBD) diagnosis and treatment
ICD-10 Coding for Rheumatology
Support Organizations


The role of laboratory testing in the treatment of arthritis and autoimmune disease

Rheumatoid Arthritis: Diagnosis, Treatment and Monitoring

 

Webinar: Statistical/epidemiological review of RA

Dr. Martin J. Bergman of Drexel University discusses the current epidemiology and statistics surrounding rheumatoid arthritis (RA). Dr. Bergman also reviews the appropriate uses and limitations of laboratory testing in reaching this serious, even potentially lethal, diagnosis. 
 

 Laboratory Testing in the Diagnosis and Management of RA and PA

 

Webinar: Laboratory testing for RA diagnosis

Following an overview of rheumatoid arthritis (RA), Dr. Martin Bergman of Drexel University reviews the role of lab testing in diagnosing RA and psoriatic arthritis (PsA), monitoring disease activity and identifying medical toxicities. He also stresses the importance of lab screening prior to disease-modifying antirheumatic drugs (DMARDS) or biologic therapy.  
 

 Clinical Focus - Osteoarthritis and Rheumatoid Arthritis

 

Clinical Focus: Arthritis laboratory markers

This paper discusses the various tests for differentiating rheumatoid arthritis (RA) from osteoarthritis and other conditions. It covers criteria for diagnosing osteoarthritis in different joints; testing that supports RA diagnosis, prognosis and follow-up; and reactivity of rheumatoid factor (RF), cyclic citrullinated antibody (CCP Ab) and 14-3-3 eta assays in various disorders.  
 

 Disease Awareness Rheumatoid and Psoriatic Arthritis Fact Sheet

 

Disease Awareness Fact Sheet:
Early arthritis testing and diagnosis

Read about the common symptoms of rheumatoid (RA) and psoriatic (PsA) arthritis and, given that joint damage is irreversible, the vital importance of early diagnosis and treatment. This fact sheet also covers the various tests available and how to interpret results. 
 

 Dr. Martin Bergman

 

Expert Insights Newsletter: Arthritis:
The central role of testing

Dr. Martin Bergman, Clinical Associate Professor of Medicine, Drexel University College of Medicine, reviews the role of laboratory testing in diagnosis, screening and monitoring drug toxicity. 
 

 ANA - the Misunderstood Lab Test

 

Webcast: ANA—The misunderstood lab test

Dr. Martin Bergman, Clinical Associate Professor of Medicine, Drexel University College of Medicine, discusses what he calls the “misunderstood” family of ANA tests for autoimmune diseases and reviews guidelines for when ANA testing is (or is not) appropriate. 
 

 Autoimmune Rheumatic and Related Diseases

 

Test Guide: Diagnosing rheumatic disorders

ANA (Antinuclear Antibody) immunofluorescence assay (IFA), the gold standard recommended by the American College of Rheumatology for screening rheumatic disorders and the most comprehensive approach to diagnosing rheumatic diseases. Other specific antibody tests include immunoassay methods such as multiplex and ELISA. This guide includes a table of guidelines for testing and interpretation, plus a useful testing algorithm.
 

 Autoimmune FAQ

 

FAQ: Tests for Autoimmune Disease

Refer to this FAQ for answers to common questions about autoimmune disease testing, including definitions, diagnosis, prevalence among certain demographic groups, significance of different ANA patterns, test ordering and interpretation of results. 
 

 Autoimmune antibody chart

 

Chart: Autoantibody Prevalence in Autoimmune Disease

This chart shows the prevalence of certain autoantibodies in common autoimmune diseases. Because these autoantibodies are considered predictive markers, they can help determine the diagnosis, the degree of organ or system involvement and the extent of damage.


2014 TR 2 Target (T2T) Guidelines

 Treating Rheumatoid Arthritis to Target 2014

 

CME Webcast: Treating Rheumatoid Arthritis
To Target (T2T)

Dr. Martin J. Bergman of Drexel University discusses the current epidemiology and statistics surrounding rheumatoid arthritis (RA). Dr. Bergman also reviews the appropriate uses and limitations of laboratory testing in reaching this serious, even potentially lethal, diagnosis. 


Biomarkers and early diagnosis

 New Arthritis Biomarkers Mean New Hope

 

Lecture: New arthritis biomarkers mean new hope

Dr. Martin Bergman of Drexel University discusses new biomarkers that can help distinguish osteoarthritis (OA), a common arthritic disorder, from rheumatoid arthritis, a rarer and far more serious form of the disease. Because rapid and aggressive therapy is necessary to reduce disease activity and prevent joint deformity, it’s absolutely vital that RA be diagnosed accurately
and early. 
 

 Dr. Martin Bergman

 

Expert Insights Newsletter:
Making early detection a priority

According to Dr. Martin Bergman, early detection of rheumatoid arthritis (RA) makes it far easier to control the disease and improve outcomes. In this issue of Expert Insights, Dr. Bergman reviews the protocol for diagnosing and treating RA. He also looks to new and emerging biologic markers that could lead to more effective diagnoses and treatment recommendations.


Spotlight on 14-3-3 eta

 Insights from our arthritis and autoimmune expert

 

Insights from our arthritis and autoimmune expert

In this article, Stanley J. Naides, MD, discusses the need for new biomarkers in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), currently available blood tests, and the clinical gap. Dr. Naides educates on a breakthrough biomarker, 14-3-3 eta, and reviews its pathogenetic mechanism and the scientific basis for its use as a diagnostic test, as well as its ability to differentiate Osteoarthritis (OA) and other inflammatory diseases.  

 Personalized Medicine in RA: The Role of Biomarkers

 

CME Video: The search for an optimal RA biomarker

The panelists discuss the need for an “ideal” biomarker for rheumatoid arthritis, one that would aid in diagnosis and correlate with disease activity and/or progression. The focus is 14-3-3 eta, a complement to CCP (ACPA*) and RF that could potentially predict both future clinical phenotypes and possibly structural damage.
 

 New Biomarker 14-3-3eta: Advances in Diagnosing Early RA and Differentiating Osteoarthritis

Webinar: Comparing arthritis biomarkers

Dr. Walter Maksymowych of the University of Alberta compares rheumatoid arthritis (RA) and osteoarthritis (OA). He discusses the antibodies commonly used to differentiate the two diseases, RF and anti-CCP antibodies, and how some of their limitations can be overcome by the new 14-3-3 eta biomarker.
 

 14-3-3eta protein webinar Dr. Maksymowych

 

Webinar: Introduction to the new
14-3-3 eta biomarker

Dr. Walter Maksymowych of the University of Alberta discusses the pathophysiology of 14-3-3 eta, an inflammatory mediator with diagnostic and prognostic value for rheumatoid arthritis. The webinar also reviews the clinical relevance of a new assay used to measure 14-3-3 eta.  
 

 14-3-3 is a novel mediator associated with the pathogenesis of RA and joint damage

 

Research: 14-3-3 eta and the pathophysiology
of rheumatoid arthritis

This 2014 article from Arthritis, Research & Therapy reviews a study of 14-3-3 eta, a protein isoform that regulates cellular signaling processes. The study finds that 14-3-3 eta induces factors known to contribute to the pathophysiology of rheumatoid arthritis and indicates more severe disease in both early and established disease.
 

 Serum 14-3-3 is a Novel Marker that Complements Current Serological Measurements to Enhance Detection of Patients with RA
 

Research Study: Understanding the
14-3-3 eta mediator

This 2014 study from the Journal of Rheumatology assesses the utility of serum 14-3-3 eta, a novel joint-derived proinflammatory mediator, in diagnosing rheumatoid arthritis (RA). In the study, serum 14-3-3 eta successfully differentiated RA patients from healthy individuals and all controls. 
 

 Rheumatoid and Psoriatic Arthritis

 

Disease Awareness Newsletter: Arthritis primer

This fact sheet reviews common symptoms of rheumatoid and psoriatic arthritis. It lays out a strategy for early diagnosis, which is considered crucial for slowing or even halting disease progression. You’ll also learn about 14-3-3 eta, a protein for differentiating RA from other autoimmune disorders with similar symptoms.
 

 Dr. Maksymowych

 

Expert Insights Newsletter:
Reaching an early arthritis diagnosis

This article by Dr. Maksymowych discusses the challenge of diagnosing arthritis early and citing shortcomings in both testing and clinician training. Following a review of current diagnostic options, the article introduces a new clinical tool based on a protein, 14-3-3 eta, that has been associated with various inflammatory processes relevant to rheumatoid arthritis.


Irritable bowel disease (IBD) diagnosis and treatment

 IBD Algorithm

 

Algorithm: Diagnosing IBD

Clinicians can use this simple algorithm to help diagnose inflammatory bowel disease (IBD). It can also determine whether an IBD diagnosis is differentiated from Crohn’s disease and ulcerative colitis. 
 

 IBD Clinical Focus

 

Menu: IBD test options

Inflammatory bowel disease (IBD) is usually diagnosed on the basis of clinical, radiographic, endoscopic and histologic findings. This menu lists the tests useful in making an IBD differential diagnosis.  


ICD-10 Coding for Rheumatology

 ACR Quest ICD-10 Crosswalk

 

Guide: Rheumatology ICD-10 Crosswalk

ICD diagnosis codes for rheumatology changed in October 2015. This quick reference chart shows the new ICD-10 codes, code mapping and guidelines for the most common diagnoses in rheumatology. 


Support organizations 

The organizations below serve patients with various autoimmune diseases, their families and friends, and the medical professionals responsible for their care. You’ll find educational material, information about symptoms, diagnosis and treatment, FAQs, scientific data and tips on getting involved locally, plus a host of other helpful tools and resources.

American Autoimmune Related Diseases Association 

American College of Rheumatology

Arthritis Foundation

Autoimmunity Network

Kids Get Arthritis Too

Lupus Foundation of America

National Psoriasis Foundation

NORD (National Organization for Rare Disorders)

Orpha.net

Scleroderma Foundation

Sjorgren’s Syndrome Foundation

The Myositis Association

* ACPA is the European version of CCP


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