Instant Insight: Metabolic Risk Panel

Instant Insight: Metabolic Risk Panel  (PODCAST TRANSCRIPT)

[00:00:00] Welcome to Healthier World with Quest Diagnostics. Our goal is to prompt action from Insight as we keep you up to date on current clinical and diagnostic topics in cardiovascular, metabolic, endocrine, and wellness medicine.

[00:00:19] Hey listeners, Welcome to a special episode designed to give you instant insights on a test offering called the metabolic risk panel

[00:00:26] today, we'll be reviewing four components that are included in the metabolic risk panel,

[00:00:31] Including an A1C insulin resistance panel with score illiquid panel and an April lipoprotein B.

[00:00:39] This is perhaps my favorite test offering from a clinical perspective

[00:00:43] Because it's addressing the needTo identify individuals with metabolic dysfunction,

[00:00:47] which is driven by insulin resistance. And has becoming a huge epidemic in our current population. As a society, we are less active in eating more sugar, which is driving up our risk for insulin resistance.

[00:00:59] In fact, 30 million us adults have progressed to type two diabetes. As a result of the increase in obesity and metabolic risk,

[00:01:07] There are costly related conditions that are also affected namely cardiovascular disease, metabolic dysfunction associated stereotonic liver disease, chronic kidney disease, and others. In fact, the increase rates. Of obesity and metabolic syndrome are driving up cardiovascular disease, which is the number one cause of death globally in both men and women.

[00:01:27] The consensus among the experts is that early identification and intervention is crucial. In order to delay and prevent disease progression. So, what do we do? How do we catch risk early?

[00:01:40] thinking about blood-based markers that would predict issues with glycaemic control and cardiovascular risk. It might be common for you to think of an HB A1C and a standard lipid panel. However, adding evidence-based biomarkers like apolipoprotein B and an insulin resistance panel with a score can better identify individuals at risk,

[00:02:00] let's first start by talking about the metabolic risk panel components that assess glycaemic control. Hemoglobin A1C or HBA. One C is many providers, frontline defense for assessing metabolic issues, especially now that the center of Medicare and Medicaid services . Recognizes HBA one C as a covered diabetes screen in certain populations.

[00:02:20] But now we have better tools than just HBA. One C alone.

[00:02:24] The foundation of glycemic control is a condition called insulin resistance, which is when insulin is working really hard to keep our HBA one C levels down. Eventually the body stops responding well to the signal of insulin. And importantly, this is a condition that can be present up to 10 years before a type two diabetes diagnosis.

[00:02:44] And well, before you would see a rise in fasting glucose or A1C. Thus, assessing a marker for insulin resistance is crucial.

[00:02:52] The insulin resistance panel with score uses LCMS technology and combines fasting insulin, and C-peptide to evaluate the likelihood of being insulin resistant. Now insulin resistance panel with score and A1C. are both clear measures Of glycemia control, but importantly, metabolic dysfunction can also influence lipids. Most providers are already ordering a standard lipid panel.

[00:03:16] The important thing to keep in mind is that lipids like cholesterol and triglycerides do not mix with blood. They're like oil and water and they need to be packaged into particles to get to where they need to go.

[00:03:28] Insulin resistance drives poor packaging and leads to an increase in the number of

[00:03:33] particles. In circulation. Because it is the particles.

[00:03:37] that get trapped in the artery wall and lead to atherosclerotic buildup risk tracks with particles. Each risk carrying particle contains exactly one

[00:03:46] apolipoprotein B or APO B molecule on it. thus counting the Applebee's quantify the number of risks, carrying particles in circulation.

[00:03:55] Apolipoprotein B is especially important in patients with high triglycerides above one 50. Metabolic syndrome. And insulin resistance as these populations are at greater risk of having higher APO B. Then we'll be expected based on their standard lipid panel.

[00:04:12] The assessment of APO B is applicable for Primary prevention patients, as well as patients who are already on lipid lowering medications to better identify cardiovascular risk.

[00:04:23] (The metabolic risk panel is a comprehensive and powerful group of tests that take a standard evaluation like a lipid panel and hbA1c, and adds depth by including IR score and ApoB to refine risk assessmment. Having these tests together on the same panel helps identify the root cause of cardiometbaolic risk, and will help catch risk early.dont forget to tune into our previous podcasts that take a deeper dive on ApoB and IR score for more details. by understanding these biomarkers, you can take proactive steps toward managing wellness and reducing risk for chronic conditions. )

[00:04:23] The metabolic risk panel is a comprehensive and powerful group of tests that take a standard evaluation, like a lipid panel and an HBA one C and adds depth by including an insulin resistance panel with score and an April lipoprotein B To

[00:04:37] refine risk assessment. Having these tests together on the same panel helps to identify the root cause of cardio-metabolic risk and helps to catch this early. Don't forget to tune into our previous episodes that take a deeper dive on April lipoprotein B an insulin resistance panel with score. By understanding these biomarkers, you can take proactive steps to managing wellness and reducing risks for chronic conditions.

[00:05:02] That's a wrap on this episode of Healthier World with Quest Diagnostics. Please follow us on your favorite podcast app, and be sure to check out Quest Diagnostics Clinical Education Center for more resources, including educational webinars and research publications. Thank you for joining us today as we work to create a healthier world, one life at a time.