Thyroid testing

Get enhanced insights for diagnosing and managing thyroid disorders

Thyroid disorders have many etiologies, manifestations, and potential therapies. Quest Diagnostics offers solutions that can help you diagnose, treat, and monitor every type of thyroid disease.

Get guideline-based thyroid testing from the lab that knows endocrinology

Testing from Quest Diagnostics can help you diagnose, treat, monitor, and prevent complications related to every type and etiology of thyroid disease.

Quest’s broad range of endocrinology tests are aligned to the most recent clinical practice guidelines—including those from the American Thyroid Association (ATA) and American Association of Clinical Endocrinologists (AACE)—for better disease management.

Key thyroid tests from Quest

Test Code Test Name Recommended Clinical Use
899 TSH

Detects TSH levels for differential diagnosis of primary, secondary, and tertiary hypothyroidism; also useful in screening for hyperthyroidism

867 T4 (Thyroxine), Total

Used to help diagnose hypothyroidism and hyperthyroidism

861 T3 Uptake

Used with measurement of thyroxine (T4) to calculate the free T4 index to assess thyroid diseases

866 T4 Free (FT4)

Used to diagnose hypothyroidism and hyperthyroidism

35167 T4 Free, Direct Dialysis

Used for the differential diagnosis of euthyroid hyperthyroxinemia from hyperthyroidism or for the differential diagnosis of euthyroid hypothyroxinemia from hypothyroidism

7444 Thyroid Panel with TSH

Includes T3 Uptake; T4 (Thyroxine), Total; Free T4 Index (T7); TSH

A complete panel used to diagnose hypothyroidism and hyperthyroidism

7260 Thyroid Peroxidase and Thyroglobulin Antibodies

Useful in the diagnosis and management of a variety of thyroid disorders, including autoimmune thyroiditis, Hashimoto’s disease, Graves’ Disease, and certain types of goiter

90810 Thyroglobulin, LC/MS/MS

Used in the detection of residual or recurrent thyroid cancer

30551 TSI (Thyroid Stimulating Immunoglobulin)

Used to detect Graves’ disease; can also assist in predicting hyperthyroidism in neonates

5738 TRAb (TSH Receptor Binding Antibody)

Used to diagnose and manage Graves’ disease, neonatal hypothyroidism, and postpartum thyroid dysfunction

90814 Thyroid Cancer (Thyroglobulin) Monitor

If thyroglobulin antibody is negative, thyroglobulin is tested on the Beckman Coulter DxI; if thyroglobulin antibody is positive, thyroglobulin is tested by LC/MS/MS

Used for the determination of thyroglobulin autoantibodies, with subsequent measurement of thyroglobulin

Thyroid disorders and causes

Hypothyroidism (underactive thyroid) and hyperthyroidism (overactive thyroid) are the most common thyroid disorders.

Common causes of these disorders include immune system disorders Graves’ disease, for hyperthyroidism, and Hashimoto’s disease, for hypothyroidism.

References

1. American Thyroid Association. General information/press room. Available at www.thyroid.org/media-main/about-hypothyroidism. Accessed March 30, 2018.

2. Nussey S, Whitehead S. Chapter 3: The thyroid gland. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers; 2001.

3. Pramyothin P, Leung AM, Pearce EN, et al. Clinical problem-solving. A hidden solution. N Engl J Med. 2011;365(22):2123–2137.

4. Ginsberg J, Lewanczuk RZ, Honore LH. Hyperplacentosis: A novel cause of hyperthyroidism. Thyroid. 2001;11:393–396.

5. Patil-Sisodia K, Mestman JH. Graves hyperthyroidism and pregnancy: A clinical update. Endocr Pract. 2010;16(1):118–129.

6. Flynn RV, MacDonald TM, Morris AD, et al. The thyroid epidemiology, audit and research study; thyroid dysfunction in the general population. J Clin Endocrinol Metab, 2004;89:3879–3884.

7. Tamai H, Kasagi K, Takaichi Y. Development of spontaneous hypothyroidism in patients with Graves’ disease treated with antithyroidal drugs: clinical, immunological, and histological findings in 26 patients. J Clin Endocrinol Metab. 1989;69(1):49–53.

8. Hancock SL, Cox RS, McDougall IR. Thyroid diseases after treatment of Hodgkin’s disease. N Engl J Med. 1991;325(9):599–605.

9. Buisset E, Leclerc L, Lefebvre J-L, et al. Hypothyroidism following combined treatment for hypopharyngeal and laryngeal carcinoma. Am J Surg. 1991;162:345–347.

10. UCLA Endocrine Surgery Encyclopedia. Secondary hypothyroidism. Available at www.uclahealth.org/endocrine-center/hypothyroidism-secondary. Accessed March 30, 2018.

11. DeGroot LJ. Graves’ disease and the manifestations of thyrotoxicosis. 2015. Available at www.ncbi.nlm.nih.gov/books/NBK285567. Accessed March 30, 2018.

12. Ginsburg J. Diagnosis and management of Graves’ disease. CMAJ. 2003;168(5):575–585.

13. Stern RA, Robinson B, Thorner AR, et al. A survey study of neuropsychiatric complaints in patients with Graves’ disease. J Neuropsychiatry Clin Neurosci. 1996;8(2):181–185.

14. Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988–1028.

15. American Thyroid Association. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016:26(10):1343–1423.