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Comprehensive and Guideline-based Hereditary Cancer Panels

Comprehensive Hereditary Cancer Panel

The Comprehensive Hereditary Cancer Panel includes 66 genes associated with a broad spectrum of hereditary cancers. This can include, but is not limited to, cancers of the breast, colon, endometrium, ovary, pancreas, prostate, rectum, neuroendocrine system, and other tissues. This panel would be used if the clinician desires comprehensive analysis of genes related to a variety of cancers containing clinically actionable genes as well as emerging genes.

Test name

Test code

GSP or CPT coding

FAQ

Comprehensive Hereditary Cancer Panel (66 genes)
Multi-cancer, 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2

38600

For breast: 81432, 81433

For colon: 81435, 81436

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Guideline-Based Hereditary Cancer Panel

The Guideline-Based Hereditary Cancer Panel includes clinically actionable analysis of 32 genes including moderate to high risk to provide clinically actionable results that give you a clearer picture of your patient’s potential risk for hereditary cancers, including breast, colon, prostate, uterine, melanoma, and other hereditary cancers.. This panel would be used if the clinician desires comprehensive analysis of genes related to more common cancers.

Test name

Test code

GSP or CPT coding

Guideline-Based Hereditary Cancer Panel (32 genes)

Multi-cancer, 32-gene panel tests for variants in these genes: APC, ATM, AXIN2, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p16,p14), CHEK2, EPCAM, GREM1, HOXB13, MLH1, MSH2, MSH3, MSH6, MUTYH, NF1, NTHL1, PALB2, POLD1, POLE, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53

38611

For breast: 81432, 81433

For colon: 81435, 81436

Hereditary cancer genetic testing guide

Download our hereditary cancer reference guide for an overview of our tests, genes included in each test, and associated cancers (gene association based on guidelines and internal data).
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Test codes may vary by location. Please contact your local laboratory for more information.

Components of panels may be ordered separately.

The CPT® codes provided are based on American Medical Association guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Helping you understand test results

We have created reports to help you and your patients better understand hereditary cancer test results.
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Only a patient’s treating physician can make diagnoses, prognostic or treatment decisions based on the knowledge of the patient, history and clinical/educational experience. Quest lab testing provides information for the physician to use in helping make such decisions.

Questions? Connect with a team member.

Please talk to your Quest representative for ordering information on our comprehensive portfolio of hereditary cancer test offerings.

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Solid Tumor Cancers

Hematology

Hereditary Cancer

Resources

Overview brochure

Reference guide

Clinician guide

Pocket risk guide

Clinical Education Center

Requisition

Clinical history form - English

Clinical history form - Spanish

Patient questionnaire

Letter of medical necessity

Variant IQ™ Family Insight Program: application form

Proband consent form

Family member consent form

Pedigree form

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